路海滨

作者: 时间:2021-06-22 点击数:

姓名

路海滨

职称

副教授

办公地点

伟德betvlctor1946609

办公电话

13756285943

邮箱

haibin1025@163.com

教育背景

2006-2009 吉林老员工命科学学院 博士研究生 2004-2006 BETVLCTOR伟德官方网站 硕士研究生 2000-2004 BETVLCTOR伟德官方网站 本科生

工作经历

2016-至今, BETVLCTOR伟德唯一官网, 伟德betvlctor1946, 副教授/硕士生导师

2010-2016, BETVLCTOR伟德唯一官网, 伟德betvlctor1946, 讲师

主讲课程

1、天然药物化学 2、波谱解析

研究领域

新药设计与合成

科研成果

论文:

(1) Li YJ, Li YQ, Yang L, Liu Z, Zhang RM, Zhen XW, Lu HB*,Wang SS* (2021), Design, synthesis and biological evaluation as immunosuppressant of amino alcohol derivatives containing thioether, Mater. Express,11(5), 773-780.

(2) Mu XP, Bai LT,Xu YJ, Wang JY, Lu HB* (2020), Protein targeting chimeric molecules specific for dual bromodomain 4 (BRD4) and Polo - like kinase 1 (PLK1) proteins in acute myeloid leukemia cells, Biochem Biophys Res Commun, 521(4): 833- 839.

(3) Wang SH, Li HY, Wang Y, Gao Y, YU SS, Zhao QQ, Jin XQ, Lu HB* (2018), Design and Synthesis of Proteolysis Targeting Chimeras for Inducing BRD4 Protein Degradation, Chemical Research in Chinese Universities, 34(2): 221-228.

(4) Wang SH, SONG YM, Wang Y, Gao Y, Yu SS, Zhao QQ, Jin XQ, Lu HB* (2018), Design and Synthesis of Novel Bispecific Molecules for Inducing BRD4 Protein Degradation, Chemical Research in Chinese Universities, 2018, 34(1): 67-74.

(5) Lu HB, Jin XQ, Jin Y, Huang BR, Wang C, Wang CH, Mu XP* (2016), Design, synthesis, inhibiting HDACs ability and antitumor activity of pyrimidin-4(3H)-one hydroxamate derivatives, Chemical Research in Chinese Universities, 32(4): 576-580.

(6) Mao CY, Lu HB, Kong N* (2014), Levocarnitine Protects H9c2 Rat Cardiomyocytes from H2O2-induced Mitochondrial Dysfunction and Apoptosis, International Journal of Medical Sciences, 11(11), 1107-1115

(7) Mao C, Yang P, Wang Y, Qiao L, Chen B, Wang S, Xu Y, Lu HB* (2013), Synthesis, Evaluation of Analgesic and Gastric Ulcerogenic Activities and the Metabolites in Rat Plasma of Hydantoin Ibuprofen Conjugates, Letters in Drug Design & Discovery, 10, 895-899.

(8) Lu HB, Wang SH, Li QM, Wang YS* (2013), Design, Synthesis and Evaluation of 6-Oxo-1,6-dihydropyrimidine-2,5-dicarboxamide Derivatives as MMP13 Inhibitors, Chemical Research in Chinese Universities, 29(1), 67-70.

(9) Lu HB, Kong DJ, Wu B, Wang SH, Wang YS (2012), Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives, Letters in Drug Design & Discovery, 2012, 9(6), 638-642.

专利:

(1) 路海滨;邓嘉玉;高洋;王月;封明明;郭彧;苏润萍;金向群;靶向泛素化降解PLK1和BRD4蛋白的化合物及其应用,2019-12-06, CN201611000114.1;

(2) 路海滨;王诗惠;李海燕;王春贺;邓嘉玉;封明明;郭彧;苏润萍;金向群;一种靶向泛素化降解PLK1和BRD4蛋白的化合物及其应用,2017-12-15, CN201610991723.1.

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