科研项目 作为课题负责人获得过自然科学基金项目、科技部项目，主要有： 1. 国家重点研发计划中医药现代化研究，2018YFC1706105，珍稀濒危中药资源新来源的四种开发模式研究，2018/012-2021/12，135万元，子课题主持； 2. 国家“重大新药创制”科技重大专项，2013ZX09103002-007，治疗病毒性肝炎创新药物-YCZT的研究，20013/01-2016/12，112万元，已结题，主持； 3. 国家“重大新药创制”科技重大专项，2009ZX09502-011，中药药效物质基础及物质资源库研究关键技术，2009/01-2010/12，40万元，已结题，子课题主持； 4. 国家支撑计划，2006BAI06A18-17，中药五类新药刺人参苷的研究，2006/10-2009/10，40万元，已结题，主持； 5. 国家重点科技项目（攻关）计划，k94-14-01-03，抗恶性肿瘤新药人参甙-Rh2的研制，1996/01-1997/12，20万元，已结题，主持； 6. 国家自然科学基金面上项目，29302006，东北刺人参三萜皂甙有效成分研究，1994/01-1996/12，5万元，已结题。 Scientific research project hosted: 1.The national key research and development plans to modern research of traditional Chinese medicine, 2018 YFC1706105, four kinds of development pattern research on new sources of rare and endangered traditional Chinese medicine resources. 2.State "major drug discovery" science and technology major projects, 2013 ZX09103002-007, innovative drugs in the treatment of viral hepatitis-YCZT research. 3.The state "major drug discovery" science and technology major projects, 2009 ZX09502-011, traditional Chinese medicine medicinal material base, research on the key technologies of material resource. 4.The state support plan, 2006BAI06A18-17, Research of the fifth class of new Chinese medicine drugs, Cirenshen glycosides. 5.The national key project of science and technology (sci) plan, k94-14-01-03, research of new anti-malignant tumor drug , ginsenoside Rh2. 6.The national natural science foundation of China, 29302006, Studies on active triterpenoid saponins of Oplopanax elatus 近五年的代表性学术论文： Representative academic papers of nearly five years: 1. Triterpenoid saponins from the herb Hylomecon japonica, Phytochemistry, 2020, 181, 112542. 2. Design, Synthesis and Biological Evaluation of 1-Phenyl-2-(phenylamino) Ethanone Derivatives as Novel MCR-1 Inhibitors, Molecules 2019, 24, 2719. 3. Simultaneous determination of six bioactive components of total flavonoids of Scorzonera austriaca in rat tissues by LC-MS/MS: application to a tissue distribution study, Revista Brasileira de Farmacognosia 28 (2018) 156-164. 4. New Triterpenoid Saponins from the Herb Hylomecon japonica, Molecules 2017, 22, 1731. 5. Development of an LC–MS/MS method for quantification of two pairs of isomeric flavonoid glycosides and other ones in rat plasma: Application to pharmacokinetic studies, Biomedical Chromatography. 2017;e3972. 6. Preparative Separation and Purification of the Total Flavonoids in Scorzonera austriaca with Macroporous Resins, Molecules, 2016, 21(6): 768. 7. Flavonoid Glycosides and Their Derivatives from the Herbs of Scorzonera austriacaWild, Molecules, 2016, 21(6): 803. 8. Pheonolic Compounds from the Fruits of Viburnum sargentii Koehne, Molecules, 2015, 20(8): 14377-14385. |
