科研成果 |
论文： (1) Li YJ, Li YQ, Yang L, Liu Z, Zhang RM, Zhen XW, Lu HB*，Wang SS* (2021), Design, synthesis and biological evaluation as immunosuppressant of amino alcohol derivatives containing thioether, Mater. Express，11(5), 773-780. (2) Mu XP， Bai LT，Xu YJ, Wang JY, Lu HB* (2020), Protein targeting chimeric molecules specific for dual bromodomain 4 (BRD4) and Polo - like kinase 1 (PLK1) proteins in acute myeloid leukemia cells, Biochem Biophys Res Commun, 521(4): 833- 839. (3) Wang SH, Li HY, Wang Y, Gao Y, YU SS, Zhao QQ, Jin XQ, Lu HB* (2018), Design and Synthesis of Proteolysis Targeting Chimeras for Inducing BRD4 Protein Degradation, Chemical Research in Chinese Universities, 34(2): 221-228. (4) Wang SH, SONG YM, Wang Y, Gao Y, Yu SS, Zhao QQ, Jin XQ, Lu HB* (2018), Design and Synthesis of Novel Bispecific Molecules for Inducing BRD4 Protein Degradation, Chemical Research in Chinese Universities, 2018, 34(1): 67-74. (5) Lu HB, Jin XQ, Jin Y, Huang BR, Wang C, Wang CH, Mu XP* (2016), Design, synthesis, inhibiting HDACs ability and antitumor activity of pyrimidin-4(3H)-one hydroxamate derivatives, Chemical Research in Chinese Universities, 32(4): 576-580. (6) Mao CY, Lu HB, Kong N* (2014), Levocarnitine Protects H9c2 Rat Cardiomyocytes from H2O2-induced Mitochondrial Dysfunction and Apoptosis, International Journal of Medical Sciences, 11(11), 1107-1115 (7) Mao C, Yang P, Wang Y, Qiao L, Chen B, Wang S, Xu Y, Lu HB* (2013), Synthesis, Evaluation of Analgesic and Gastric Ulcerogenic Activities and the Metabolites in Rat Plasma of Hydantoin Ibuprofen Conjugates, Letters in Drug Design & Discovery, 10, 895-899. (8) Lu HB, Wang SH, Li QM, Wang YS* (2013), Design, Synthesis and Evaluation of 6-Oxo-1,6-dihydropyrimidine-2,5-dicarboxamide Derivatives as MMP13 Inhibitors, Chemical Research in Chinese Universities, 29(1), 67-70. (9) Lu HB, Kong DJ, Wu B, Wang SH, Wang YS (2012), Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives, Letters in Drug Design & Discovery, 2012, 9(6), 638-642. 专利： (1) 路海滨；邓嘉玉；高洋；王月；封明明；郭彧；苏润萍；金向群；靶向泛素化降解PLK1和BRD4蛋白的化合物及其应用，2019-12-06, CN201611000114.1； (2) 路海滨；王诗惠；李海燕；王春贺；邓嘉玉；封明明；郭彧；苏润萍；金向群；一种靶向泛素化降解PLK1和BRD4蛋白的化合物及其应用,2017-12-15, CN201610991723.1. |
